GPC is an allergic reaction on the underside of the eyelids caused by what?

GPC is an allergic reaction on the underside of the eyelids caused by what?

• A. Protein deposits on contact lenses or poor CL fit
• B. Bacterial infection
• C. Traumatic injury
• D. Dry eye disease

Answer: (A)

Giant papillary conjunctivitis is an allergic/inflammatory reaction of the palpebral conjunctiva (the underside, or inner surface, of the upper eyelid) to substances associated with contact lenses. The most common trigger is protein deposits on contact lenses or a lens fit that is poor or irritating. When lenses accumulate proteins or rub the lid margins, the eye becomes sensitized and large papillae form on the tarsal conjunctiva, creating the characteristic “giant” papillary response under the lid. That makes protein deposits on lenses or a poorly fitting lens the best explanation for this finding. Bacterial infection can cause conjunctivitis but not the specific giant papillary changes; dry eye causes irritation without this marked papillary reaction; traumatic injury can cause inflammation but not the lens-related allergic papillae described here.

Giant papillary conjunctivitis is an allergic/inflammatory reaction of the palpebral conjunctiva (the underside, or inner surface, of the upper eyelid) to substances associated with contact lenses. The most common trigger is protein deposits on contact lenses or a lens fit that is poor or irritating. When lenses accumulate proteins or rub the lid margins, the eye becomes sensitized and large papillae form on the tarsal conjunctiva, creating the characteristic “giant” papillary response under the lid. That makes protein deposits on lenses or a poorly fitting lens the best explanation for this finding. Bacterial infection can cause conjunctivitis but not the specific giant papillary changes; dry eye causes irritation without this marked papillary reaction; traumatic injury can cause inflammation but not the lens-related allergic papillae described here.